SODIUM SULPHOMETHYL DERIVATIVES OF POLYMYXINS
نویسندگان
چکیده
منابع مشابه
Novel derivatives of polymyxins.
Polymyxin B and colistin (polymyxin E) are bactericidal pentacationic lipopeptides that act specifically on Gram-negative bacteria, first by disrupting their outermost permeability barrier, the outer membrane (OM), and then damaging the cytoplasmic membrane. Both were discovered in the mid-1950s and subsequently used in intravenous therapy, but soon largely abandoned because of nephrotoxicity. ...
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Although the value of polymyxins B and E in the treatment of infections with Gram-negative bacilli is well recognized, they are not usually used unless the causal organisms are insensitive to antibiotics with wider activity. In consequence, sensitivity tests for them are not common laboratory procedures and it is not generally appreciated that the usual methods are not entirely satisfactory. Ju...
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In a recent article, Garonzik et al. (4) importantly advanced our knowledge of the pharmacokinetics (PK) of colistin methanesulfonate (CMS) and the active drug that it forms, colistin. In their elegant population PK study of critically ill patients, the authors demonstrated that creatinine clearance (CLCR) significantly affects the total body clearance of CMS and colistin (4). It is important t...
متن کاملDose Adjustment of Polymyxins for Renal Insufficiency
In a recent article, Garonzik et al. (4) importantly advanced our knowledge of the pharmacokinetics (PK) of colistin methanesulfonate (CMS) and the active drug that it forms, colistin. In their elegant population PK study of critically ill patients, the authors demonstrated that creatinine clearance (CLCR) significantly affects the total body clearance of CMS and colistin (4). It is important t...
متن کاملDose adjustment of polymyxins for renal insufficiency.
In a recent article, Garonzik et al. (4) importantly advanced our knowledge of the pharmacokinetics (PK) of colistin methanesulfonate (CMS) and the active drug that it forms, colistin. In their elegant population PK study of critically ill patients, the authors demonstrated that creatinine clearance (CLCR) significantly affects the total body clearance of CMS and colistin (4). It is important t...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1964
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1964.tb01610.x